Cyclotrimerization by a membrane protein based cobalt-biohybrid catalyst

20/07/2018
 

Cooperation with Prof. Okuda group results in a joint publication

Congratulations to Stephanie Mertens and Daniel Sauer on their recent publication!

The main focus of the interdisciplinary cooperation with the Prof. Okuda group from the Institute of Inorganic Chemistry at RWTH Aachen is the development of new protein based biohybrid catalysts. A modified (η5-Cyclopentadienyl) cobalt (I) catalyst was designed in the Institute of Inorganic Chemistry and covalently attached to a modified variant of the transmembrane protein Ferric hydroxamate uptake protein component A. The catalytic activity of the biohybrid catalyst was studied using the cyclotrimerization of phenylacetylene. 1,2,4- und 1,3,5-Triphenylbenzenecould be obtained in a 2:1 ratio in aqueous solution. This work was realized in the divisions Hybrid catalysis & HTS and NGBC and it was possible through DFG - SeleCa (Selectivity in Chemo- and Biocatalysis) funding.

To learn more, please access the full paper on Publications an Patents and

Thiel, D. F. Sauer, S. Mertens, T. Polen and H. Chen, U. Schwaneberg, J. Okuda, Org. Biomol. Chem., 2018

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